Microbial laboratory evolution in the era of genome-scale science.

TitleMicrobial laboratory evolution in the era of genome-scale science.
Publication TypeJournal Article
Year of Publication2011
AuthorsConrad TM, Lewis NE, Palsson BØ
JournalMol Syst Biol
Volume7
Pagination509
PubMed Date2011-7-8
ISSN1744-4292
KeywordsAdaptation, Physiological, Escherichia coli, Evolution, Molecular, Gene Expression Regulation, Bacterial, Genome, Bacterial, Models, Molecular, Mutation, Phenotype
Abstract

Laboratory evolution studies provide fundamental biological insight through direct observation of the evolution process. They not only enable testing of evolutionary theory and principles, but also have applications to metabolic engineering and human health. Genome-scale tools are revolutionizing studies of laboratory evolution by providing complete determination of the genetic basis of adaptation and the changes in the organism's gene expression state. Here, we review studies centered on four central themes of laboratory evolution studies: (1) the genetic basis of adaptation; (2) the importance of mutations to genes that encode regulatory hubs; (3) the view of adaptive evolution as an optimization process; and (4) the dynamics with which laboratory populations evolve.

Alternate JournalMol. Syst. Biol.
PubMed ID21734648

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