|Title||Evaluation of rate law approximations in bottom-up kinetic models of metabolism.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Du B, Zielinski DC, Kavvas ES, Dräger A, Tan J, Zhang Z, Ruggiero KE, Arzumanyan GA, Palsson BO|
|Journal||BMC Syst Biol|
BACKGROUND: The mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters. The parameterization challenge is often addressed through the use of simplifying approximations to form reaction rate laws with reduced numbers of parameters. Whether such simplified models can reproduce dynamic characteristics of the full system is an important question.
|Alternate Journal||BMC Syst Biol|
Evaluation of rate law approximations in bottom-up kinetic models of metabolism.