Engineering of oleaginous organisms for lipid production.

TitleEngineering of oleaginous organisms for lipid production.
Publication TypeJournal Article
Year of Publication2015
AuthorsLevering J, Broddrick J, Zengler K
JournalCurr Opin Biotechnol
Volume36
Pagination32-39
PubMed Date08/2015
ISSN1879-0429
Abstract

Phototrophs are attractive candidates for commercial lipid production. Lipid biosynthetic pathways in these organisms have been largely characterized but the mechanisms partitioning resources toward storage lipids are poorly understood. One promising strategy to study and enhance biomass lipid bioproduction in oleaginous microorganisms is to combine genome-scale metabolic modeling and genetic and metabolic engineering. Here we describe recent advances in in vitro, in vivo, and in silico manipulations of phototrophic metabolism that increase total lipid content or redirect lipid production toward more favorable products such as polyunsaturated fatty acids used as nutritional supplements or in biofuel production.

Alternate JournalCurr. Opin. Biotechnol.
PubMed ID26319892
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