|Title||SBMLsqueezer 2: context-sensitive creation of kinetic equations in biochemical networks.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Dräger A, Zielinski DC, Keller R, Rall M, Eichner J, Palsson BO, Zell A|
|Journal||BMC Syst Biol|
BACKGROUND: The size and complexity of published biochemical network reconstructions are steadily increasing, expanding the potential scale of derived computational models. However, the construction of large biochemical network models is a laborious and error-prone task. Automated methods have simplified the network reconstruction process, but building kinetic models for these systems is still a manually intensive task. Appropriate kinetic equations, based upon reaction rate laws, must be constructed and parameterized for each reaction. The complex test-and-evaluation cycles that can be involved during kinetic model construction would thus benefit from automated methods for rate law assignment.
|Alternate Journal||BMC Syst Biol|
SBMLsqueezer 2: context-sensitive creation of kinetic equations in biochemical networks.