Applications of genome-scale metabolic reconstructions.

Title Applications of genome-scale metabolic reconstructions.
Year of Publication 2009
Authors M.A. Oberhardt; B.Ø. Palsson; J.A. Papin
Journal PLoS Comput Biol
Abstract The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.
URL PubMed