I am a postdoctoral researcher in the Palsson lab.

Currently, I'm working on the systems-level understanding of biohydrogen production by Thermotoga maritima.

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Education

2007, Ph.D. Food Science & Biotechnology, Seoul National University, Korea (Advisor: Jin-Ho Seo)

2003, M.S. Food Science & Biotechnology, Seoul National University, Korea (Advisor: Jin-Ho Seo)

2000, B.A. Food Science & Technology, Seoul National University, Korea

Research Experience

Postdoctoral Researcher, Aug. 2007 - present, Systems Biology Research Group, Department of Bioengineering, University of California, San Diego

Research Scientist, Mar. 2007 - July 2007, Research Institute for Agriculture and Life Sciences, Seoul National University, Korea

Visiting Fellow, Aug. 2005 - Oct. 2005, School of Chemical and Biomolecular Engineering, Cornell University

Honors and Awards

Graduation with Summa Cum Laude, Department of Food Science & Technology, Seoul National University, Korea, 2000

Publications

Dae-Hee Lee, Adam M. Feist and Bernhard O. Palsson, 2010, Cumulative number of cell divisions in Escherichia coli as a meaningful time-scale for laboratory adaptive evolution, (submitted to AEM).

Dae-Hee Lee, Nathan E. Lewis and Bernhard O. Palsson, 2010, Optimal metabolic states on unnatural substrates form through laboratory adaptive evolution, (in preparation).

Dae-Hee Lee, Ye-Ji Lee, Yeon-Woo Ryu, and Jin-Ho Seo, 2010, "Molecular cloning and biochemical characterization of a novel erythrose reductase from Candida magnoliae JH110", Microbial Cell Factories 9: 43.

Dae-Hee Lee and Bernhard O. Palsson, 2010, "Adaptive evolution of Escherichia coli K-12 MG1655 on a non-native carbon source, L-1,2-Propanediol", Applied and Environmental Microbiology 76(3):4158-4168.

Dae-Hee Lee, Sung-Gun Kim, Dae-Hyuk Kweon and Jin-Ho Seo, 2009, "Folding machineries displayed on a cation-exchanger for the concerted refolding of cysteine- or proline-rich protein", BMC Biotechnology 9:27.

Dae-Hee Lee, Myoung-Dong Kim, Yeon-Woo Ryu and Jin-Ho Seo, 2008, "Cloning and characterization of CmGPD1, the Candida magnoliae homologue of glycerol 3-phosphate dehydrogenase", FEMS Yeast Research 8(8): 1324-1333.

Ji-Hee Yu, Dae-Hee Lee, Yong-Cheol Park, Mi-Gi Lee, Dae-Ok Kim, Yeon-Woo Ryu and Jin-Ho Seo, 2008, "Proteomic analysis of fructophilic properties of osmotolerant Candida magnoliae", Journal of Microbiology and Biotechnology, 18(2): 248-254.

Dae-Hee Lee, Sung-Gun Kim, Yong-Cheol Park, Soo-Wan Nam, Kelvin H. Lee and Jin-Ho Seo, 2007, "Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide -1", Journal of Chromatography B, 849(2): 323-330.

Sung-Gun Kim, Jeong-Ah Kim, Hyun-Ah Yu, Dae-Hee Lee, Dae-Hyuk Kweon and Jin-Ho Seo, 2006, "Application of poly-arginine fused minichaperone to renaturation of cyclodextrin glycosyltransferase expressed in recombinant Escherichia coli", Enzyme and Microbial Technology, 39(3): 459-465.

Ji-Hee Yu, Dae-Hee Lee, Yong-Joo Oh, Ki-Cheol Han, Yeon-Woo Ryu and Jin-Ho Seo, 2006, "Selective utilization of fructose to glucose by Candida magnoliae, an erythritol producer", Applied Biochemistry and Biotechnology, 131(3): 870-879.

Young-Jin Cho, Dae-Hee Lee, Dae-Ok Kim, Won-Ki Min, Ki-Tae Bong, Gang-Gweon Lee and Jin-Ho Seo, 2005, "Production of monoclonal antibody against ochratoxin A and its application to immunochromatographic assay", Journal of Agricultural and Food Chemistry, 53(22): 8447-8451.

Chan-Su Rha, Dae-Hee Lee, Sung-Gun Kim, Seonng-Goo Byun, Dae-Hyuk Kweon , Nam-Soo Han and Jin-Ho Seo, 2005, "Production of cyclodextrin by poly-lysine fused Bacillus macerans cyclodextrin glycosyltransferase immobilized on cation exchanger", Journal of Molecular Catalysis B: Enzymatic, 34(1-6): 39-43.

Yong-Cheol Park, Do-Yup Lee, Dae-Hee Lee, Hyo-Jin Kim and Jin-Ho Seo, 2005, "Proteomics and physiology of erythritol producing strains", Journal of Chromatography B, 815(2): 251-260.

Won-Heong Lee, Yong-Cheol Park, Dae-Hee Lee, Kyung-Moon Park and Jin-Ho Seo, 2005, "Simultaneous biocatalyst production and Bayer-Villiger oxidation for bioconversion of cyclohexanone by recombinant Escherichia coli expressing cyclohexanone monooxygeanse", Applied Biochemistry and Biotechnology, 123(3):827-836.

Sung-Gun Kim, Dae-Hyuk Kweon, Dae-Hee Lee, Yong-Cheol Park and Jin-Ho Seo, 2005, "Coexpression of folding accessory proteins for production of active cyclodextrin glycosyltransferase of Bacillus macerans in recombinant Escherichia coli", Protein Expression and Purification, 41(2): 426-432.

Hyo-Jin Kim, Do-Yup Lee, Dae-Hee Lee, Yong-Cheol Park, Dae-Hyuk Kweon, Yeon-Woo Ryu and Jin-Ho Seo, 2004, "Strategic proteome analysis of Candida magnoliae with unsequenced genome", Proteomics, 4(11): 3588-3599.

Gyu-Ho Choi, Dae-Hee Lee, Won-Ki Min, Young-Jin Cho, Dae-Hyuk Kweon, Dong-Hwa Son, Kyoung-Moon Park and Jin-Ho Seo, 2004, "Cloning, expression, and characterization of single-chain variable fragment (scFv) antibody against mycotoxin deoxynivalenol in recombinant Escherichia coli", Protein Expression and Purification, 35(1): 84-92.

Dae-Hee Lee, Myoung-Dong Kim, Won-Heong Lee, Dae-Hyuk Kweon and Jin-Ho Seo, 2004, "Consortium of fold-catalyzing proteins increases soluble expression of cyclohexanone monooxygeanse in recombinant Escherichia coli", Applied Microbiology and Biotechnology, 63(5): 549-552.

Dae-Hyuk Kweon, Dae-Hee Lee, Nam-Soo Han and Jin-Ho Seo, 2004, "Solid-phase refolding of cyclodextrin glycosyltransferase adsorbed on cation-exchange resin", Biotechnology Progress, 20(1): 277-283.

Dae-Hyuk Kweon, Dae-Hee Lee, Nam-Soo Han, Chan-Su Rha and Jin-Ho Seo, 2002, "Characterization of polycationic amino acids fusion systems for ion-exchange purification of cyclodextrin glycosyltransferase from recombinant Escherichia coli", Biotechnology Progress, 18(2): 303-308.

Contact Information

Email Address: dlee@bioeng.ucsd.edu

Phone: 858 822 1144

Mailing Address: 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093-0412