Charles J. Norsigian

Research Interests

My research interests center on comparative analysis of microbial pathogens to elucidate evolutionary differences. I am focused on applying metabolic network reconstructions in concert with other computational approaches to analyze large scale biological datasets.

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2016, B.S. Biomedical Engineering, University of Virginia, Charlottesville, Virginia


Norsigian, Charles J., Erol Kavvas, Yara Seif, Bernhard O. Palsson, and Jonathan M. Monk. "iCN718, an updated and improved genome-scale metabolic network reconstruction of Acinetobacter baumannii AYE." Frontiers in genetics 9 (2018): 121.

Norsigian, Charles J., Heba Attia, Richard Szubin, Aymin Yassin, Bernhard O. Palsson, Ramy K. Aziz, and Jonathan Monk. "Comparative Genome-scale Metabolic Modelling of Metallo-beta-Lactamase–producing Multidrug-resistant Klebsiella pneumoniae Clinical Isolates."  Frontiers in Cellular and Infection Microbiology  9 (2019): 161

Norsigian, Charles J., Xin Fang, Yara Seif, Jonathan M. Monk, and Bernhard O. Palsson. "A workflow for generating multi-strain genome-scale metabolic models of prokaryotes."  Nature Protocols  (2019): 1-14.

Norsigian, Charles J., Neha Pusarla, John Luke McConn, James T Yurkovich, Andreas Dräger, Bernhard O Palsson, Zachary King, "BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree" Nucleic Acids Research  (2020)

Norsigian, Charles J., Xin Fang, Bernhard O. Palsson, and Jonathan M. Monk. "Pangenome Flux Balance Analysis Toward Panphenomes." in The Pangenome: Diversity, Dynamics, and Evolution of Genomes,   Springer   p. 219-232. (2020)

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