// Red Blood Cell metabolism with cofactor exchanges and Elemental Balances
// June 11, 2001

// EMP		
HK		I	-1 GLC	-1 ATP	+1 G6P 	+1 ADP  +1 H
PGI		R	-1 G6P	+1 F6P
PFK		I	-1 F6P	-1 ATP	+1 FDP 	+1 ADP  +1 H
ALD		R	-1 FDP	+1 DHAP	+1 GA3P
TPI		R	-1 DHAP	+1 GA3P
GAPDH		R	-1 GA3P -1 NAD	-1 PI	+1 13DPG +1 NADH +1 H
PGK		R	-1 13DPG 	-1 ADP	+1 3PG	+1 ATP
DPGM		I	-1 13DPG	+1 23DPG  +1 H
DPGase		I	-1 23DPG  -1 H2O  +1 3PG 	+1 PI
PGM		R	-1 3PG	+1 2PG
EN		R	-1 2PG	+1 PEP	+1 H2O
PK		I	-1 PEP 	-1 ADP	-1 H  +1 PYR 	+1 ATP
LDH		R	-1 PYR 	-1 NADH	-1 H	+1 LAC 	+1 NAD

// PPP
G6PDH		I	-1 G6P 	-1 NADP	+1 6PGL +1 NADPH +1 H
PGL		R	-1 6PGL -1 H2O  +1 6PGC  +1 H
PDGH		I	-1 NADP -1 6PGC +1 RL5P	+1 NADPH +1 CO2
R5PI		R	-1 RL5P	+1 R5P
Xu5PE		R	-1 RL5P	+1 X5P
TKI		R	-1 X5P  -1 R5P	+1 S7P 	+1 GA3P
TKII		R	-1 E4P 	-1 X5P	+1 GA3P +1 F6P
TA		R	-1 S7P 	-1 GA3P	+1 E4P 	+1 F6P

// Additional Rxns
AMPase	I	-1 AMP -1 H2O +1 ADO +1 PI  +1 H
ADA	I	-1 ADO -1 H2O +1 INO +1 NH3
AK	I	-1 ADO -1 ATP +1 ADP +1 AMP
ApK	R	-2 ADP +1 AMP +1 ATP
AMPDA	I	-1 AMP -1 H2O +1 IMP +1 NH3
AdPRT	I	-1 PRPP -1 ADE -1 H2O +1 AMP +2 PI
IMPase	I	-1 IMP -1 H2O +1 INO +1 PI +1 H
PNPase	R	-1 INO -1 PI +1 HX +1 R1P
PRM	R	-1 R1P	+1 R5P
PRPPsyn	I	-1 R5P -1 ATP +1 PRPP +1 AMP
HGPRT	I	-1 PRPP -1 HX -1 H2O +1 IMP  +2 PI

(Exchange Fluxes)
*primary
GLC		Input
23DPG		Output
PYR		Free
LAC		Free
HX		Output
ADE		Free
ADO		Free
INO		Free
	
*currency
ADP		Free
ATP 		Free
NAD		Free
NADH		Free
NADP		Free
NADPH		Free
PI		Free
CO2		Free
H		Free
NH3		Free
H2O 		Free