Systems glycobiology for glycoengineering.

TitleSystems glycobiology for glycoengineering.
Publication TypeJournal Article
Year of Publication2014
AuthorsSpahn PN, Lewis NE
JournalCurr Opin Biotechnol
Volume30C
Pagination218-224
PubMed Date09/2014
ISSN1879-0429
Abstract

Glycosylation serves essential functions on many proteins produced in biopharmaceutical manufacturing, making it mandatory to thoroughly consider its biogenesis during the production process. Glycoengineering efforts involve the rational design of glycosylation through adjustments in culturing conditions or genetic modifications. Computational models have been developed to aid this process, aiming to offer cheaper and faster alternatives to costly screening strategies. Recently, these models have been successfully utilized to predict glycosylation of products of industrial relevance. Furthermore, systems-level analyses of glycan diversity are elucidating deeper insights into the mechanisms underlying glycosylation. As computational models of glycosylation continue to be expanded, refined, and leveraged for detailed analysis of glycomics data, they will become invaluable resources for cell line development and glycoengineering.

Alternate JournalCurr. Opin. Biotechnol.
PubMed ID25202878
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