Constraint-based models predict metabolic and associated cellular functions.

TitleConstraint-based models predict metabolic and associated cellular functions.
Publication TypeJournal Article
Year of Publication2014
AuthorsBordbar A, Monk JM, King ZA, Palsson BO
JournalNat Rev Genet
PubMed Date2014 Feb

The prediction of cellular function from a genotype is a fundamental goal in biology. For metabolism, constraint-based modelling methods systematize biochemical, genetic and genomic knowledge into a mathematical framework that enables a mechanistic description of metabolic physiology. The use of constraint-based approaches has evolved over ~30 years, and an increasing number of studies have recently combined models with high-throughput data sets for prospective experimentation. These studies have led to validation of increasingly important and relevant biological predictions. As reviewed here, these recent successes have tangible implications in the fields of microbial evolution, interaction networks, genetic engineering and drug discovery.

Alternate JournalNat. Rev. Genet.
PubMed ID24430943
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