|Title||Capsule deletion via a lamda-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Huang T-W, Lam I, Chang H-Y, Tsai S-F, Palsson BO, Charusanti P|
|Journal||BMC Res Notes|
|PubMed Date||2014 Jan 8|
BACKGROUND: Klebsiella pneumoniae is a leading cause of hospital-acquired urinary tract infections and pneumonia worldwide, and is responsible for many cases of pyogenic liver abscess among diabetic patients in Asia. A defining characteristic of this pathogen is the presence of a thick, exterior capsule that has been reported to play a role in biofilm formation and to protect the organism from threats such antibiotics and host immune challenge.
|Alternate Journal||BMC Res Notes|
Capsule deletion via a lamda-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578.