Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites.

TitleSystems biology and biotechnology of Streptomyces species for the production of secondary metabolites.
Publication TypeJournal Article
Year of Publication2013
AuthorsHwang K-S, Kim H U, Charusanti P, Palsson BØ, Lee S Y
JournalBiotechnol Adv
Volume32
Issue2
Pagination255-268
PubMed Date11/2013
ISSN1873-1899
Abstract

Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolism at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.

Alternate JournalBiotechnol. Adv.
PubMed ID24189093
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