|Title||Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omics and modeling.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Ansong C, Deatherage BL, Hyduke D, Schmidt B, McDermott JE, Jones MB, Chauhan S, Charusanti P, Kim Y-M, Nakayasu ES, Li J, Kidwai A, Niemann G, Brown RN, Metz TO, McAteer K, Heffron F, Peterson SN, Motin V, Palsson BO, Smith RD, Adkins JN|
|Journal||Curr Top Microbiol Immunol|
|Keywords||Animals, Genomics, Host-Pathogen Interactions, Humans, Metabolomics, Proteomics, Salmonella, Systems Biology, Yersinia|
Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both outside of and within animal hosts. Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. These high-dimensional omics datasets are being integrated in selected ways to improve genome annotations, discover novel virulence-related factors, and model growth under infectious states. We will review the evolving technological approaches toward understanding complex microbial life through multi-omic measurements and integration, while highlighting some of our most recent successes in this area.
|Alternate Journal||Curr. Top. Microbiol. Immunol.|
Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omics and modeling.