Comparison of network-based pathway analysis methods.

TitleComparison of network-based pathway analysis methods.
Publication TypeJournal Article
Year of Publication2004
AuthorsPapin JA, Stelling J, Price ND, Klamt S, Schuster S, Palsson BØ
JournalTrends in biotechnology
Volume22
Issue8
Pagination400-5
PubMed Date2004 Aug
ISSN0167-7799
KeywordsAlgorithms, Computational Biology, Erythrocytes, Helicobacter pylori, Humans, Signal Transduction
Abstract

Network-based definitions of biochemical pathways have emerged in recent years. These pathway definitions insist on the balanced use of a whole network of biochemical reactions. Two such related definitions, elementary modes and extreme pathways, have generated novel hypotheses regarding biochemical network function. The relationship between these two approaches can be illustrated by comparing and contrasting the elementary modes and extreme pathways of previously published metabolic reconstructions of the human red blood cell (RBC) and the human pathogen Helicobacter pylori. Descriptions of network properties generated by using these two approaches in the analysis of realistic metabolic networks need careful interpretation.

Alternate JournalTrends Biotechnol.
PubMed ID15283984

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