The evolution of molecular biology into systems biology.

TitleThe evolution of molecular biology into systems biology.
Publication TypeJournal Article
Year of Publication2004
AuthorsWesterhoff HV, Palsson BØ
JournalNature biotechnology
Volume22
Issue10
Pagination1249-52
PubMed Date2004 Oct
ISSN1087-0156
KeywordsBiomedical Engineering, Genomics, History, 20th Century, History, 21st Century, Models, Biological, Molecular Biology, Systems Biology
Abstract

Systems analysis has historically been performed in many areas of biology, including ecology, developmental biology and immunology. More recently, the genomics revolution has catapulted molecular biology into the realm of systems biology. In unicellular organisms and well-defined cell lines of higher organisms, systems approaches are making definitive strides toward scientific understanding and biotechnological applications. We argue here that two distinct lines of inquiry in molecular biology have converged to form contemporary systems biology.

Alternate JournalNat. Biotechnol.
PubMed ID15470464

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