Properties of metabolic networks: structure versus function.

TitleProperties of metabolic networks: structure versus function.
Publication TypeJournal Article
Year of Publication2005
AuthorsMahadevan R, Palsson BØ
JournalBiophysical journal
PubMed Date2005 Jan
KeywordsAlgorithms, Biology, Biophysics, Cell Physiological Phenomena, Computational Biology, Computer Simulation, Escherichia coli, Genome, Geobacter, Kinetics, Metabolism, Models, Biological, Phenotype, Proteomics, Saccharomyces cerevisiae, Time Factors

Biological data from high-throughput technologies describing the network components (genes, proteins, metabolites) and their associated interactions have driven the reconstruction and study of structural (topological) properties of large-scale biological networks. In this article, we address the relation of the functional and structural properties by using extensively experimentally validated genome-scale metabolic network models to compute observable functional states of a microorganism and compare the "structure versus function" attributes of metabolic networks. It is observed that, functionally speaking, the essentiality of reactions in a node is not correlated with node connectivity as structural analyses of other biological networks have suggested. These findings are illustrated with the analysis of the genome-scale biochemical networks of three species with distinct modes of metabolism. These results also suggest fundamental differences among different biological networks arising out of their representation and functional constraints.

Alternate JournalBiophys. J.
PubMed ID15574705



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