The model organism as a system: integrating 'omics' data sets.

TitleThe model organism as a system: integrating 'omics' data sets.
Publication TypeJournal Article
Year of Publication2006
AuthorsJoyce AR, Palsson BØ
JournalNature reviews. Molecular cell biology
Volume7
Issue3
Pagination198-210
PubMed Date2006 Mar
ISSN1471-0072
KeywordsAnimals, Cell Physiological Phenomena, DNA, Genome, Genomics, Models, Biological, Neural Networks (Computer), Proteins, Proteome, Transcription, Genetic
Abstract

Various technologies can be used to produce genome-scale, or 'omics', data sets that provide systems-level measurements for virtually all types of cellular components in a model organism. These data yield unprecedented views of the cellular inner workings. However, this abundance of information also presents many hurdles, the main one being the extraction of discernable biological meaning from multiple omics data sets. Nevertheless, researchers are rising to the challenge by using omics data integration to address fundamental biological questions that would increase our understanding of systems as a whole.

Alternate JournalNat. Rev. Mol. Cell Biol.
PubMed ID16496022

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