Systems biology of the human red blood cell.

TitleSystems biology of the human red blood cell.
Publication TypeJournal Article
Year of Publication2006
AuthorsJamshidi N, Palsson BØ
JournalBlood cells, molecules & diseases
Volume36
Issue2
Pagination239-47
PubMed Date2006 Mar-Apr
ISSN1079-9796
KeywordsComputational Biology, Computer Simulation, Erythrocytes, Humans, Metabolic Networks and Pathways, Models, Biological, Systems Biology
Abstract

While the potential possibilities of systems biology appear to hold great promise, there are still many challenges to overcome, notably lack of complete characterization of biological components and their interactions and ways to measure these changes experimentally. The comparative simplicity of the human red cell sidesteps much of these challenges. Detailed models of human red cell metabolism have been developed for the last quarter century and continued development of these models has resulted in the ability to make functional phenotype predictions, in silico. Additionally, existing experimental proteomic and metabolomic technologies now provide the capability to perform individualized characterization of erythrocytes. While an experimentally testable systems biology model of most human cells is presently out of reach, it may be achievable with the red cell.

Alternate JournalBlood Cells Mol. Dis.
PubMed ID16533612

Location

Location

417 Powell-Focht Bioengineering Hall

9500 Gilman Drive La Jolla, CA 92093-0412

Contact Us

Contact Us

In Silico Lab:  858-822-1144

Wet Lab:  858-246-1625

FAX:   858-822-3120

Website Concerns: sbrgit@ucsd.edu

User Login