Systems biology as a foundation for genome-scale synthetic biology.

TitleSystems biology as a foundation for genome-scale synthetic biology.
Publication TypeJournal Article
Year of Publication2006
AuthorsBarrett CL, Kim T Y, Kim H U, Palsson BØ, Lee S Y
JournalCurrent opinion in biotechnology
Volume17
Issue5
Pagination488-92
PubMed Date2006 Oct
ISSN0958-1669
KeywordsBiology, Computational Biology, Evolution, Molecular, Genome, Models, Biological, Software, Systems Biology
Abstract

As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.

Alternate JournalCurr. Opin. Biotechnol.
PubMed ID16934450

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