A genome-scale, constraint-based approach to systems biology of human metabolism.

TitleA genome-scale, constraint-based approach to systems biology of human metabolism.
Publication TypeJournal Article
Year of Publication2007
AuthorsMo ML, Jamshidi N, Palsson BØ
JournalMolecular bioSystems
Volume3
Issue9
Pagination598-603
PubMed Date2007 Sep
ISSN1742-206X
KeywordsComputational Biology, Genome, Human, Humans, Metabolic Networks and Pathways, Software, Systems Biology
Abstract

The recent sequencing and annotation of the human genome enables a new era in biomedicine that will be based on an interdisciplinary, systemic approach to the elucidation and treatment of human disease. Reconstruction of genome-scale metabolic networks is an important part of this approach since networks represent the integration of diverse biological data such as genome annotations, high-throughput data, and legacy biochemical knowledge. This article will describe Homo sapiens Recon 1, a functionally tested, genome-scale reconstruction of human cellular metabolism, and its capabilities for facilitating the understanding of physiological and disease metabolic states.

Alternate JournalMol Biosyst
PubMed ID17700859

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