Microbial regulatory and metabolic networks.

TitleMicrobial regulatory and metabolic networks.
Publication TypeJournal Article
Year of Publication2007
AuthorsCho B-K, Charusanti P, Herrgard MJ, Palsson BØ
JournalCurrent opinion in biotechnology
Volume18
Issue4
Pagination360-4
PubMed Date2007 Aug
ISSN0958-1669
KeywordsBacterial Proteins, Fungal Proteins, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Fungal, Mass Spectrometry, Metabolic Networks and Pathways, Oligonucleotide Array Sequence Analysis, Protein Array Analysis
Abstract

Reconstruction of transcriptional regulatory and metabolic networks is the foundation of large-scale microbial systems and synthetic biology. An enormous amount of information including the annotated genomic sequences and the genomic locations of DNA-binding regulatory proteins can be used to define metabolic and regulatory networks in cells. In particular, advances in experimental methods to map regulatory networks in microbial cells have allowed reliable data-driven reconstruction of these networks. Recent work on metabolic engineering and experimental evolution of microbes highlights the key role of global regulatory networks in controlling specific metabolic processes and the need to consider the integrated function of multiple types of networks for both scientific and engineering purposes.

Alternate JournalCurr. Opin. Biotechnol.
PubMed ID17719767

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