The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.

TitleThe growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.
Publication TypeJournal Article
Year of Publication2008
AuthorsFeist AM, Palsson BØ
JournalNature biotechnology
Volume26
Issue6
Pagination659-67
PubMed Date2008 Jun
ISSN1546-1696
KeywordsBiotechnology, Chromosome Mapping, Escherichia coli, Escherichia coli Proteins, Models, Biological, Proteome, Signal Transduction
Abstract

The number and scope of methods developed to interrogate and use metabolic network reconstructions has significantly expanded over the past 15 years. In particular, Escherichia coli metabolic network reconstruction has reached the genome scale and been utilized to address a broad spectrum of basic and practical applications in five main categories: metabolic engineering, model-directed discovery, interpretations of phenotypic screens, analysis of network properties and studies of evolutionary processes. Spurred on by these accomplishments, the field is expected to move forward and further broaden the scope and content of network reconstructions, develop new and novel in silico analysis tools, and expand in adaptation to uses of proximal and distal causation in biology. Taken together, these efforts will solidify a mechanistic genotype-phenotype relationship for microbial metabolism.

Alternate JournalNat. Biotechnol.
PubMed ID18536691

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