Understanding human metabolic physiology: a genome-to-systems approach.

TitleUnderstanding human metabolic physiology: a genome-to-systems approach.
Publication TypeJournal Article
Year of Publication2009
AuthorsMo ML, Palsson BØ
JournalTrends in biotechnology
PubMed Date2009 Jan
KeywordsChromosome Mapping, Computer Simulation, Gene Expression Regulation, Genome, Humans, Models, Biological, Proteome, Signal Transduction, Systems Biology

The intricate nature of human physiology renders its study a difficult undertaking, and a systems biology approach is necessary to understand the complex interactions involved. Network reconstruction is a key step in systems biology and represents a common denominator because all systems biology research on a target organism relies on such a representation. With the recent development of genome-scale human metabolic networks, metabolic systems analysis is now possible and has initiated a shift towards human systems biology. Here, we review the important aspects of reconstructing a bottom-up human metabolic network, the network's role in modeling human physiology and the necessity for a community-based consensus reconstruction of human metabolism to be established.

Alternate JournalTrends Biotechnol.
PubMed ID19010556



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