Applications of genome-scale metabolic reconstructions.

TitleApplications of genome-scale metabolic reconstructions.
Publication TypeJournal Article
Year of Publication2009
AuthorsOberhardt MA, Palsson BØ, Papin JA
JournalMolecular systems biology
Volume5
Pagination320
PubMed Date2009
ISSN1744-4292
KeywordsBiological Evolution, Genetic Engineering, Genome, Metabolic Networks and Pathways, Models, Genetic
Abstract

The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.

Alternate JournalMol. Syst. Biol.
PubMed ID19888215

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