|Title||Applications of genome-scale metabolic reconstructions.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Oberhardt MA, Palsson BØ, Papin JA|
|Journal||Molecular systems biology|
|Keywords||Biological Evolution, Genetic Engineering, Genome, Metabolic Networks and Pathways, Models, Genetic|
The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.
|Alternate Journal||Mol. Syst. Biol.|