Applications of genome-scale metabolic reconstructions.

TitleApplications of genome-scale metabolic reconstructions.
Publication TypeJournal Article
Year of Publication2009
AuthorsOberhardt MA, Palsson BØ, Papin JA
JournalMolecular systems biology
PubMed Date2009
KeywordsBiological Evolution, Genetic Engineering, Genome, Metabolic Networks and Pathways, Models, Genetic

The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.

Alternate JournalMol. Syst. Biol.
PubMed ID19888215



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