The biomass objective function.

TitleThe biomass objective function.
Publication TypeJournal Article
Year of Publication2010
AuthorsFeist AM, Palsson BØ
JournalCurrent opinion in microbiology
Volume13
Issue3
Pagination344-9
PubMed Date2010 Jun
ISSN1879-0364
KeywordsBiomass, Cell Growth Processes, Energy Metabolism, Escherichia coli, Eukaryotic Cells, Hybridomas, Metabolic Networks and Pathways, Metabolome, Models, Theoretical, Saccharomyces cerevisiae, Systems Biology
Abstract

Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.

Alternate JournalCurr. Opin. Microbiol.
PubMed ID20430689

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