|Title||Pseudogene repair driven by selection pressure applied in experimental evolution.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Anand A, Olson CA, Yang L, Sastry AV, Catoiu E, Choudhary KSonal, Phaneuf PV, Sandberg TE, Xu S, Hefner Y, Szubin R, Feist AM, Palsson BO|
Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.
|Alternate Journal||Nat Microbiol|
Pseudogene repair driven by selection pressure applied in experimental evolution.