Pseudogene repair driven by selection pressure applied in experimental evolution.

TitlePseudogene repair driven by selection pressure applied in experimental evolution.
Publication TypeJournal Article
Year of Publication2019
AuthorsAnand A, Olson CA, Yang L, Sastry AV, Catoiu E, Choudhary KSonal, Phaneuf PV, Sandberg TE, Xu S, Hefner Y, Szubin R, Feist AM, Palsson BO
JournalNat Microbiol
PubMed Date01/2019
ISSN2058-5276
Abstract

Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.

Alternate JournalNat Microbiol
PubMed ID30692668
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