|Title||solveME: fast and reliable solution of nonlinear ME models.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Yang L, Ma D, Ebrahim A, Lloyd CJ, Saunders MA, Palsson BO|
BACKGROUND: Genome-scale models of metabolism and macromolecular expression (ME) significantly expand the scope and predictive capabilities of constraint-based modeling. ME models present considerable computational challenges: they are much (>30 times) larger than corresponding metabolic reconstructions (M models), are multiscale, and growth maximization is a nonlinear programming (NLP) problem, mainly due to macromolecule dilution constraints.
|Alternate Journal||BMC Bioinformatics|
solveME: fast and reliable solution of nonlinear ME models.