Publications
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2018. Systems biology as an emerging paradigm in transfusion medicine.. BMC Syst Biol. 12(1):31.
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2017. Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics.. Sci Rep. 7:46249.
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2017. Mannose and fructose metabolism in red blood cells during cold storage in SAGM.. Transfusion.
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2017. Quantitative time-course metabolomics in human red blood cells reveal the temperature dependence of human metabolic networks.. J Biol Chem.
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2017. Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism.. Sci Rep. 7:41241.
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2016. Citrate metabolism in red blood cells stored in additive solution-3.. Transfusion. 57(2):325-336.
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2016. A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.. Cell Syst. 3(5):434-443.e8.
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2016. Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes.. Transfusion.
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2016. Metabolic fate of adenine in red blood cells during storage in SAGM solution.. Transfusion.
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2016. Multi-omic data integration enables discovery of hidden biological regularities.. Nat Commun. 7:13091.
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2016. A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism.. PLoS Comput Biol. 12(7):e1005039.
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2015. Do genome-scale models need exact solvers or clearer standards? Mol Syst Biol. 11(10):831.
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2015. Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis.. Nat Commun. 6:7101.
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2014. Constraint-based models predict metabolic and associated cellular functions.. Nat Rev Genet. 15(2):107-20.
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2014. Minimal metabolic pathway structure is consistent with associated biomolecular interactions.. Mol Syst Biol. 10(7):737.
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2014. Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance.. Sci Rep. 4:3925.
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2014. A Systems Approach to Predict Oncometabolites via Context-Specific Genome-Scale Metabolic Networks.. PLoS Comput Biol. 10(9):e1003837.
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2012. Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation.. Mol Syst Biol. 8:558.
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2012. Multiscale Modeling of Metabolism and Macromolecular Synthesis in E. coli and Its Application to the Evolution of Codon Usage.. PLoS One. 7(9):e45635.
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2011. iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states.. BMC Syst Biol. 5:110.
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2011. A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology.. BMC Syst Biol. 5:180.
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2011. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0.. Nat Protoc. 6(9):1290-307.
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2010. Functional characterization of alternate optimal solutions of Escherichia coli's transcriptional and translational machinery.. Biophysical journal. 98(10):2072-81.
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2010. Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions.. Molecular systems biology. 6:422.
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2010. Large-scale in silico modeling of metabolic interactions between cell types in the human brain.. Nature biotechnology. 28(12):1279-85.
