Research Interests
My research interests center on comparative analysis of microbial pathogens to elucidate evolutionary differences. I am focused on applying metabolic network reconstructions in concert with other computational approaches to analyze large scale biological datasets.
Education
2016, B.S. Biomedical Engineering, University of Virginia, Charlottesville, Virginia
Publications
Norsigian, Charles J., Erol Kavvas, Yara Seif, Bernhard O. Palsson, and Jonathan M. Monk. "iCN718, an updated and improved genome-scale metabolic network reconstruction of Acinetobacter baumannii AYE." Frontiers in genetics 9 (2018): 121. https://doi.org/10.3389/fgene.2018.00121
Norsigian, Charles J., Heba Attia, Richard Szubin, Aymin Yassin, Bernhard O. Palsson, Ramy K. Aziz, and Jonathan Monk. "Comparative Genome-scale Metabolic Modelling of Metallo-beta-Lactamase–producing Multidrug-resistant Klebsiella pneumoniae Clinical Isolates." Frontiers in Cellular and Infection Microbiology 9 (2019): 161https://doi.org/10.3389/fcimb.2019.00161
Norsigian, Charles J., Xin Fang, Yara Seif, Jonathan M. Monk, and Bernhard O. Palsson. "A workflow for generating multi-strain genome-scale metabolic models of prokaryotes." Nature Protocols (2019): 1-14. https://doi.org/10.1038/s41596-019-0254-3
Norsigian, Charles J., Neha Pusarla, John Luke McConn, James T Yurkovich, Andreas Dräger, Bernhard O Palsson, Zachary King, "BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree" Nucleic Acids Research (2020) https://doi.org/10.1093/nar/gkz1054
Norsigian, Charles J., Xin Fang, Bernhard O. Palsson, and Jonathan M. Monk. "Pangenome Flux Balance Analysis Toward Panphenomes." in The Pangenome: Diversity, Dynamics, and Evolution of Genomes, Springer p. 219-232. (2020) https://doi.org/10.1007/978-3-030-38281-0_10
Contact Information
Email Address: cnorsigi@eng.ucsd.edu